Katalin F. Medzihradszky
Position
Professional Research Chemist/Adjunct Professor of Pharmaceutical Chemistry
Education
| Ph.D. | Organic Chemistry | 1981 | Eötvös Lóránd University, Budapest, Hungary |
| M.Sc. | Organic Chemistry | 1976 | Eötvös Lóránd University, Budapest, Hungary |
Work History
| 2006-Present: | Adjunct Professor, Department of Pharmaceutical Chemistry, UCSF, CA |
| 2006-Present: | Professional Research Biochemist, Department of Pharnaceutical Chemistry, UCSF, CA |
| 2004-2006: | Associate Adjunct Professor, Department of Pharmaceutical Chemistry, UCSF, CA | 2000-Present: | Head of the Proteomics Research Group/Mass Spectrometry Facility, Biological Research Center of the Hungarian Academy of Sciences, Szeged, Hungary. |
| 1996-2006: | Associate Research Biochemist, Department of Pharnaceutical Chemistry, UCSF, CA |
| 1993-1996: | Assistant Research Biochemist, Department of Pharmaceutical Chemistry, UCSF, CA |
| 1991-1993: | Assistant Research Chemist, Department of Pharmaceutical Chemistry, UCSF, CA |
| 1988-1991: | Postdoctoral Fellow, Department of Pharmaceutical Chemistry, UCSF, CA |
| 1980-1987: | Scientist, Gedeon Richter Ltd., Budapest, Hungary |
| 1980-1987: | Scientist, Central Research Institute of Chemistry/Chinoin, Budapest, Hungary |
Research Interests
mass spectrometry; collision-induced dissociation; protein analysis, proteomics, post-translational modifications; glycosylation; phosphorylation, sulfation; side-reactions.
Service to Professional Publications
2004 - Molecular & Cellular Proteomics - Editorial Board
Ad hoc referee for journals J. Am. Soc. Mass Spectrom.; Anal. Chem.; FEBS Letters; Rapid Commun Mass Spectrom
Select Publications
Darula Z, Medzihradszky KF. Affinity-enrichment and characterization of mucin core 1-type glycopeptides from bovine serum, Mol Cell Proteomics 2009 Aug 12. [Epub ahead of print] [Pubmed]
Chalkley RJ, Baker PR, Medzihradszky KF, Lynn AJ, Burlingame AL. In-depth analysis of tandem mass spectrometry data from disparate instrument types, Mol Cell Proteomics. 7(12) 2386-98 (2008). [Pubmed]
Hansell E, Braschi S, Medzihradszky KF, Sajid M, Debnath M, Ingram J, Lim KC, McKerrow JH. Proteomic analysis of skin invasion by blood fluke larvae, PLoS Negl Trop Dis. 2(7) e262 (2008). [Pubmed]
Medzihradszky KF, Guan S, Maltby DA, Burlingame AL. Sulfopeptide fragmentation in electron-capture and electron-transfer dissociation, J Am Soc Mass Spectrom. 18(9) 1617-24 (2007). [Pubmed]
Tomizawa M, Talley TT, Maltby D, Durkin KA, Medzihradszky KF, Burlingame AL, Yalor P, Casida JE. Mapping the elusive neonicotinoid binding site, Proc Nat Acad Sci USA 104(21) 9075-9080 (2007). [Pubmed]
Medzihradszky, K.F., Zhang, X., Chalkley, R.J., Guan, S., McFarland, M.A., Chalmers, M.J., Marshall, A.G., Diaz, R.L., Allis, C.D., and Burlingame, A.L., Characterization of Tetrahymena histone H2B variants and postranslational populations by electron capture dissociation (ECD) Fourier transform mass spectrometry (FTMS), Moll Cell Proteomics, 3, 872-886 (2004). [Pubmed]
Perlson, E., Medzihradszky, K.F., Darula, Z., Munno, D., Syed, N., Burlingame, A.L., and Fainzilber, M., Differential proteomics reveals multiple components in retrogradely transported axoplasm after nerve injury, Moll Cell Proteomics, 3, 510-520 (2004). [Pubmed]
Medzihradszky, K.F., Darula., Z., Perlson, E., Fainzilber, M., Chalkley, R.J., Ball, H., Greenbaum, D., Bogyo, M., Tyson, D.R., Bradshaw, R.A., and Burlingame, A.L., O-Sulfonation of serine and threonine - mass spectrometric detection and characterization of a new posttranslational modification in diverse proteins throughout the eukaryotes, Moll Cell Proteomics, 3, 429-440 (2004). [Pubmed]
Yasothornsrikul, S., Greenbaum, D., Medzihradszky, K.F., Toneff, T., Bundey, R., Miller, R., Schilling, B., Petermann, I., Dehnert, J., Logvinova, A., Goldsmith, P., Neveu, J.M., Lane, W.S., Gibson, B.W., Reinheckel, T., Peters, C., Bogyo, M., and Hook, V., Cathepsin L in secretory vesicles functions as a prohormone-processing enzyme for production of the enkephalin peptide neurotransmitter, Proc Natl Acad Sci, 100, 9590-9595 (2003). [Pubmed]
Medzihradszky, K.F., Campbell, J.M., Baldwin, M.A., Falick, A.M., Juhasz, P., Vestal, M.A., and Burlingame, A.L., The Characteristics of Peptide Collision-Induced dissociation using a high performance MALDI-TOF/TOF Tandem Mass Spectrometer, Anal Chem, 72, 552-558 (2000). [Pubmed]