Program

This Symposium has Concluded

August: 18 | 19 | 20 | 21 | 22 | 23

Saturday, August 18

Symposium and Mini-Symposium Registration
Grand Ballroom Vestibule

3:00pm Registration

Sunday, August 19

Symposium and Mini-Symposium Registration
Grand Ballroom Vestibule

7:30am Registration

Mini-Symposium on Protein Quantitation and Dynamics
Grand Ballroom

Chair: Simon Gaskell, University of Manchester, Manchester, United Kingdom

8:30am MS.1 Quantitative Proteomics: An Overview
Ruedi Aebersold, Institute for Molecular Systems Biology, ETH Zurich and Institute for Systems Biology, Seattle, WA, USA
9:30 MS.2 Profiling Protein Expression by Label-Free Quantitative Mass Spectrometry
Pedro Cutillas, Bart’s Institute of Cancer, Queen Mary University of London, United Kingdom
10:10 Coffee break
10:50 MS.3 Profiling Unlabeled Peptide Ions: A Versatile Approach to Quantitative Proteomics and to Mapping of Post-Translational Modifications
Pierre Thibault, Université de Montréal, Montréal, Canada
11:30 MS.4 Quantitative Approaches for Analysis of Regulatory Post-Translational Modifications
Jeffrey Gorman, Queensland Institute of Medical Research, Royal Brisbane Hospital, Herston, Queensland, Australia
12:10pm Lunch

Chair: John Stults, Genentech, South San Francisco, CA

1:40pm MS.5 Quantification by Spectral Counting in Large Datasets
Eric Deutsch, Institute for Systems Biology, Seattle, WA, USA
2:20 MS.6 Protein Abundance Ratios for Microbial Proteomes
Murray Hackett, University of Washington, Seattle, WA, USA
3:00 MS.7 Quantitative Proteomics in the Context of Systems Biology
Simon Gaskell, The University of Manchester, Manchester, United Kingdom
3:40 MS.8 Analysis of Protein Levels and Phosphorylation Stoichiometry from Complex Samples using the iTRAQ Reagent
Jonathan Trinidad, University of California, San Francisco, CA, USA

Grand Ballroom Vestibule

4:00pm Symposium Registration

Gold & Venetian Rooms

4:00pm Symposium Poster Set-up

Pavilion Room

6:00pm Opening Reception

Monday, August 20

Grand Ballroom Vestibule

7:15am Registration

Symposium
Grand Ballroom

8:15am Introduction

Chair: Ralph Bradshaw, University of California, San Francisco, CA

8:30am 1.1 Plenary Lecture
Expression Proteomics at Last: The Determination of Proteome Wide Protein Abundance Changes by SILAC and High Resolution Mass Spectrometry
Matthias Mann, Max-Planck Institute for Biochemistry, Martinsried, Germany

Chair: Jan van Oostrum, Novartis Institutes of BioMedical Research, Basel, Switzerland

9:30am 1.2 Statistical Analysis of Quantitative Proteomics Datasets via Normalized Spectral Abundance Factors
Michael Washburn, Stowers Institute for Medical Research, Kansas City, MO, USA
10:10 Coffee break
10:30 1.3 Insight Into Cell Biology from Physical and Genetic Protein Interactions
Gerard Cagney, Conway Institute, University College Dublin, Dublin, Ireland
11:10 1.4 Exploiting peptide identification databases for improved bioinformatics for proteomics
Simon Hubbard, University of Manchester, Manchester, United Kingdom
11:50 1.5 Refining Peptide LC/MS Analysis for Qualitative and Quantitative Proteomics
Clive Slaughter, St. Jude Children’s Research Hospital, Memphis, TN, USA
12:30pm Lunch

Chair: John Stults, Genentech, South San Francisco, CA, USA

2:00pm 2.1 Deciphering the Dynamics of Proteasome Interacting Proteins Using Quantitative Mass Spectrometry
Lan Huang, University of California, Irvine, CA, USA
2:40 2.2 The Proteome Biology of Proteasome Complexes: Molecular Organization, Function, and Regulation
Peipei Ping, University of California, School of Medicine, Los Angeles, CA, USA
3:20 2.3 Identification of Newly Synthesized Proteins Using Bioorthogonal Noncanonical Amino Acid Tagging (BONCAT)
Erin Schuman, Howard Hughes Medical Institute, California Institute of Technology, Pasadena, CA, USA

Symposium Poster Session A
Gold & Venetian Rooms

Co-Chairs: David Maltby and Frank Li, University of California, San Francisco, CA

4:00pm Poster Session A

Tuesday, August 21

Symposium
Grand Ballroom

Chair: Simon Gaskell, University of Manchester, Manchester, United Kingdom

8:30am 3.1 Plenary Lecture
Innovative Technology for the Study of Cell Signaling
Donald Hunt, University of Virginia, Charlottesville, VA, USA

Chair: Steve Carr, Broad Institute of MIT and Harvard, Cambridge, MA, USA

9:30am 3.2 TiMAC - A New Phosphoproteomic Strategy for the Separation of Mono- From Multiply Phosphorylated Peptides Combined with Optimized Tandem MS Mass Spectrometric Analysis
Martin Larsen, University of Southern Denmark, Odense, Denmark
10:10 Coffee break
10:30 3.3 Proteomic Study of a Steroid Signal Transduction Pathway in Plants
Zhi-Yong Wang, Carnegie Institute, Stanford, CA, USA
11:10 3.4 Comprehensive Phosphoproteome Analyses of Leukemic Hematopoietic Stem Cells to Uncover the Molecular Basis of Self-Renewal
Pierre Thibault, Université de Montréal, Montréal, Canada
11:50 3.5 New Technology to Detect and Monitor the Post-Translational Modification Events that Commit Human Embryonic Stem Cells to Exit the Pluripotent State
Joshua Coon, University of Wisconsin, Madison, WI, USA
12:30pm Lunch

Chair: Ralph Bradshaw, University of California, San Francisco, CA

2:00pm 4.1 Interrogation of Cellular Signalling Pathways Using Protein Microarrays
Jan van Oostrum, Novartis Institutes of BioMedical Research, Basel, Switzerland
2:40 4.2 Dynamic Interplay Between GlcNAc and Phosphate on Regulatory Proteins
Gerald Hart, Johns Hopkins University School of Medicine, Baltimore, MD, USA
3:20 4.3 Mass Spectrometry as a Detector for Protein Ubquitination
Steven Gygi, Harvard Medical School, Boston, MA, USA

Symposium Poster Session B
Gold & Venetian Rooms

Co-Chairs: Shenheng Guan and Juan Oses-Prieto, University of California, San Francisco, CA, USA

4:00pm Poster Session B

Wednesday, August 22

Symposium
Grand Ballroom

Chair: John Stults, Genentech, South San Francisco, CA, USA

8:30am 5.1 Systems-Wide Analysis of Protein Complexes in Saccharomyces cerevisiae
Anne-Claude Gavin, European Molecular Biology Laboratory, Heidelberg, Germany
9:10 5.2 Degradomics: the Proteolysis of Cell Death
James A. Wells, University of California, San Francisco, CA, USA
9:50 5.3 Characterization of GSK3 Dependent Circadian Phosphoproteome
Krista Kaasik, University of California, San Francisco, CA, USA
10:30 Coffee break

Chair: Ralph Bradshaw, University of California, San Francisco, CA, USA

10:50am 5.4 Plenary Lecture
Interactome Networks
Marc Vidal, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA
11:50 Lunch

Chair: Gerard Cagney, Conway Institute, University College Dublin, Ireland, United Kingdom

1:20pm 6.1 The Study of Organelle Dynamics Using Stable Isotope Labeling
Kathryn Lilley, University of Cambridge, United Kingdom
2:00 6.2 Elucidating Interacting Regions Within a Large Protein Complex Through Chemical Crosslinking and Mass Spectrometry
Gerald Carlson, University of Kansas Medical Center, Kansas City, KS, USA

Symposium Poster Session C

Co-Chairs: Katalin Medzihradszky and Mike Trnka, University of California, San Francisco, CA, USA

2:40pm Poster Session C

Symposium Dinner

6:00pm Conference Dinner Reception
Fountain/Crystal Rooms
7:00 Conference Dinner
Crown Room

Thursday, August 23

Symposium
Grand Ballroom

Chair: A. L. Burlingame, University of California, San Francisco, CA, USA

8:30am 7.1 Sperm Chromatin Proteomics Identifies Evolutionarily Conserved Fertility Factors
Diana Chu, San Francisco State University, CA, USA
9:10 7.2 Walking in the Proteomic Footprints of Viral Infection
Ileana Cristea, Rockefeller University, New York, NY, USA
9:50 7.3 Exploiting Viruses to Identify Critical Interactions and Therapeutic Targets in the Cellular Networks That Regulate Growth and Survival
Clodagh O’Shea, Salk Institute for Biological Studies, La Jolla, CA, USA
10:30 Coffee break
11:00 7.4 High Throughput Characterization of Amplified Nucleic Acids by ESI-TOF Mass Spectrometry: Applications in Pathogen Detection and Characterization
Steven Hofstadler, Ibis Biosciences, Carlsbad, CA, USA
11:40 Lunch

Chair: John Stults, Genentech, South San Francisco, CA, USA

1:40pm 8.1 Exploration of the Human Muscle Proteome in Diabetes
Susan Weintraub, University of Texas Health Science Center, San Antonio, TX, USA
2:20 8.2 Protein Biomarker Identification in the Cerebrospinal Fluid in Patients with Central Nervous System Lymphoma
James Rubenstein, University of California, San Francisco, CA, USA
3:00 8.3 Progress Toward a Biomarker Discovery-to-Verification Pipeline in Clinical Proteomics
Steven A. Carr, Broad Institute of MIT and Harvard, Cambridge, MA, USA

Chair: A. L. Burlingame, University of California, San Francisco, CA, USA

3:40pm 8.4 Plenary Lecture
The Protein Microscope: An Application of Cell Map Proteomics
John J.M. Bergeron, McGill University, Montreal, Canada
4:40pm Closing remarks
5:00 Adjourn

National Institute of General Medical SciencesAdelson Medical Research Foundation