Anatoly Urisman

Anatoly Urisman

Position

Assistant Professor

Email

anatoly.urisman@ucsf.edu

Education

M.D. Medicine 2008 University of California, San Francisco
Ph.D. Biomedical Sciences 2006 University of California, San Francisco

Work History

2016-Present: Assistant Professor, Department of Pathology, University of California, San Francisco
2014-2016: Clinical Instructor, Department of Pathology, University of California, San Francisco
2011-2014: Clinical Research Fellow, Department of Pathology, University of California, San Francisco
2010-2011: Pulmonary Pathology Fellow, Department of Pathology, University of California, San Francisco
2008-2010: Residency, Anatomic Pathology, University of California, San Francisco

Research Interests

My research is focused on applying a variety of proteomic mass spectrometry-based techniques to study signaling mechanisms and regulation of signaling in a variety of human diseases. Our work is fundamentally multi-disciplinary and collaborative. The ongoing areas of interest include signaling networks in lung cancer, mechanisms of neurodegeneration, and precision medicine applications in medical kidney and medical lung diseases.

Select Publications

Castel P, Cheng A, Cuevas-Navarro A, Everman DB, Papageorge AG, Simanshu DK,Tankka A, Galeas J, Urisman A, McCormick F. RIT1 oncoproteins escape LZTR1-mediated proteolysis. Science. 2019 Mar 15; 363(6432):1226-1230. doi:10.1126/science.aav1444. PubMed PMID: 30872527. [Pubmed]

Wong AW, Urisman A, Burlingame AL, Shokat KM. Chemically reprogramming the phospho-transfer reaction to crosslink protein kinases to their substrates. Protein Sci. 2019 Mar; 28(3):654-662. doi: 10.1002/pro.3570. Epub 2019 Jan 31. PubMed PMID: 30636329; PubMed Central PMCID: PMC6371225. [Pubmed]

Sahoo PK, Lee SJ, Jaiswal PB, Alber S, Kar AN, Miller-Randolph S, Taylor EE,Smith T, Singh B, Ho TS, Urisman A, Chand S, Pena EA, Burlingame AL, Woolf CJ,Fainzilber M, English AW, Twiss JL. Axonal G3BP1 stress granule protein limits axonal mRNA translation and nerve regeneration. Nat Commun. 2018 Aug 22; 9(1):3358. doi: 10.1038/s41467-018-05647-x. PubMed PMID: 30135423; PubMed Central PMCID: PMC6105716. [Pubmed]

Terenzio M, Koley S, Samra N, Rishal I, Zhao Q, Sahoo PK, Urisman A, Marvaldi L, Oses-Prieto JA, Forester C, Gomes C, Kalinski AL, Di Pizio A, Doron-Mandel E, Perry RB, Koppel I, Twiss JL, Burlingame AL, Fainzilber M. Locally translated mTOR controls axonal local translation in nerve injury. Science. 2018 Mar 23; 359(6382):1416-1421. doi: 10.1126/science.aan1053. PubMed PMID: 29567716. [Pubmed]

Forester CM, Zhao Q, Phillips NJ, Urisman A, Chalkley RJ, Oses-Prieto JA, Zhang L, Ruggero D, Burlingame AL. Revealing nascent proteomics in signaling pathways and cell differentiation. Proc Natl Acad Sci U S A. 2018 Mar 6; 115(10):2353-2358. doi: 10.1073/pnas.1707514115. Epub 2018 Feb 21. PubMed PMID: 29467287; PubMed Central PMCID: PMC5877968. [Pubmed]

Urisman A, Levin RS, Gordan JD, Webber JT, Hernandez H, Ishihama Y, Shokat KM, Burlingame AL. An Optimized Chromatographic Strategy for Multiplexing In Parallel Reaction Monitoring Mass Spectrometry: Insights from Quantitation of Activated Kinases. Mol Cell Proteomics. 2017 Feb; 16(2):265-277. doi: 10.1074/mcp.M116.058172. Epub 2016 Dec 11. PubMed PMID: 27940637; PubMed Central PMCID: PMC5294213. [Pubmed]

Doll S, Urisman A, Oses-Prieto JA, Arnott D, Burlingame AL. Quantitative Proteomics Reveals Fundamental Regulatory Differences in Oncogenic HRAS and Isocitrate Dehydrogenase (IDH1) Driven Astrocytoma. Mol Cell Proteomics. 2017 Jan; 16(1):39-56. doi: 10.1074/mcp.M116.063883. Epub 2016 Nov 10. PubMed PMID: 27834733; PubMed Central PMCID: PMC5217781. [Pubmed]

Lee S, Shang Y, Redmond SA, Urisman A, Tang AA, Li KH, Burlingame AL, Pak RA, Joviĉić A, Gitler AD, Wang J, Gray NS, Seeley WW, Siddique T, Bigio EH, Lee VM,Trojanowski JQ, Chan JR, Huang EJ. Activation of HIPK2 Promotes ER Stress-Mediated Neurodegeneration in Amyotrophic Lateral Sclerosis. Neuron. 2016 Jul 6; 91(1):41-55. doi: 10.1016/j.neuron.2016.05.021. Epub 2016 Jun 16. PubMed PMID: 27321923; PubMed Central PMCID: PMC4938715. [Pubmed]


National Institute of General Medical Sciences Adelson Medical Research Foundation