Juan A. Oses-Prieto
Position
Assistant Researcher
Education
| Ph.D. | Cell Biology | 1999 | University of Navarra, Pamplona, Spain |
| M.A. | Biochemistry | 1997 | University of Navarra, Pamplona, Spain |
| M.A. | Biology | 1994 | University of Navarra, Pamplona, Spain |
Work History
| 2009-Present: | Assistant Research Biochemist, Mass Spectrometry Facility, Department of Pharmaceutical Chemistry, School of Pharmacy, UCSF, CA |
| 2004-2009: | Postdoctoral Fellow, Mass Spectrometry Facility, Department of Pharmaceutical Chemistry, School of Pharmacy, UCSF, CA |
| 2001-2008: | Instructor, Department of Biochemistry, University of Navarra, Pamplona, Spain |
| 2000-2004: | Postdoctoral Fellow, Department of Cell Biology and Biophysics, University of Kansas, Kansas City, MO. (supervisors: Drs. Marino Martinez-Carrion and Ana Iriarte) |
Research Interests
To develop a greater understanding of the intimate details of the processes inside living cells requires a deep analysis of the molecular machinery involved in those activities. Proteins are the functional core of many of these mechanisms. A complex interaction network between different polypeptides regulates the activities of a large percentage of the cellular proteins. My research interest is focused on understanding how protein-protein interactions and post translational modifications regulate the activity of the molecules involved in signal transduction pathways, as well as understanding the structural molecular basis of their folding and association.
Select Publications
Bradshaw, R.A., Medzihradszky, K.F., Ruperez, P., Oses-Prieto, J.A., and Burlingame, A.L., Post translational modifications: Identifying the wheat and sorting the chaff in Proceedings of 4th International Peptide Symposium (J. Wilce, ed.) Topic: Clinical Proteomics (2008).
Tang, W., Kim, T.W., Oses-Prieto, J.A., Sun, Y., Dent, Z., Zhu, S., Wang, R., Burlingame, A.L., Wang, Z.Y., BSKs mediate signal transduction from the receptor kinase BRI1 in Arabidopsis, Science, 321(5888), 557-560 (2008). [Pubmed]
Tang, W., Deng, Z., Oses-Prieto, J.A., Suzuki, N., Zhu, S., Zhang, X., Burlingame, A.L., and Wang, Z-Y., Proteomic studies of brassinosteroid signal transduction using prefractionation and 2-D DIGE, Molecular & Cellular Proteomics, 7(4), 728-738 (2008). [Pubmed]
Oses-Prieto, J., Zhang, X., and Burlingame, A.L., Formation of epsilon-formyllysine on Silver-Stained Proteins: Implications for Assignment of Isobaric Dimethylation Sites by Tandem Mass Spectrometry, Molecular & Cellular Proteomics, 6(2), 181-192 (2007). [Pubmed]
Iacovides, D., O'Shea, C., Oses-Prieto, J., Burlingame, A., and McCormick, F., Critical role for arginine methylation in adenovirus-infected cells, Journal of Virology, 81(23), 13209-13217 (2007). [Pubmed]
Deng, Z., Zhang, X., Tang, W., Oses-Prieto, J.A., Suzuki, N., Gendron, J.M., Chen, H., Guan, S., Chalkley, R.J., Peterman, K.T., Burlingame, A.L., and Wang, Z-Y., Proteomic study of brassinosteroid response in Arabidopsis, Molecular & Cellular Proteomics, 6(12), 2058-2071 (2007). [Pubmed]
Natal, C., Oses-Prieto, J.A., Pelacho, B., Iraburu, M.J., and Lopez-Zabalza, M.J., Regulation of apoptosis by peptides of fibronectin in human monocytes, Apoptosis, 11(2), 209-219 (2006). [Pubmed]
Rodriguez-Viciana, P., Oses-Prieto, J., Burlingame, A., Fried, M., and McCormick, F., A Phosphatase Holoenzyme Comprised of Shoc2/Sur8 and the Catalytic Subunit of PP1 Functions as an M-Ras Effector to Modulate Raf Activity, Molecular Cell, 22(2), 217-230 (2006). [Pubmed]
Oses-Prieto, J.A., Bengoechea-Alonso, M., Artigues, A., Iriarte, A., and Martinez-Carrion, M., The nature of the rate-limiting steps in the refolding of the cofactor-dependent protein aspartate aminotransferase, J Biol Chem, 278(50), 49988-49999 (2003). [Pubmed]
Bengoechea-Alonso, M.T., Pelacho, B., Oses-Prieto, J.A., Santiago, E., Lopez-Moratalla, N., and Lopez-Zabalza, M.J., Regulation of NF-κB activation by NO via protein phosphatase 2B and protein kinase A activities on human monocites, Nitric Oxide, 8(1), 65-74 (2003). [Pubmed]
Montiel-Duarte, C., Varela-Rey, M., Oses-Prieto, J.A., Lopez-Zabalza, M.J., Beitia, G., Cenarruzabeitia, E., and Iraburu, M.J., 3,4-methylenedioxymethamphetamine ("Ecstasy") induces apoptosis of cultured rat liver cells, Biochimica et Biophysica Acta - Molecular Basis of Disease, 1588(1) , 26-32 (2002). [Pubmed]
Varela-Rey, M., Montiel-Duarte, C., Oses-Prieto, J.A., Lopez-Zabalza, M.J., Jaffrezou, J.P., Rojkind, M. and Iraburu, M.J., p38 MAPK mediates the regulation of α1(I)procollagen mRNA levels by TNF-α and TGF-β in a cell line of rat hepatic stellate cells, FEBS Letters, 528(1-3), 133-138 (2002). [Pubmed]
Oses-Prieto, J.A., Lopez-Moratalla, N., Santiago, E., Jaffrezou, J.P., and Lopez-Zabalza, M.J., Molecular mechanisms of apoptosis induced by immunomodulating peptides on human monocytes, Archiv Biochem Biophys, 379(2), 353-362 (2000). [Pubmed]