Jason Maynard

Jason Maynard

Position

Assistant Researcher

Email

jason.maynard@ucsf.edu

Education

Ph.D. Cell Biology 2009 Duke University, Durham, NC
B.S. Molecular Biology 2003 University of Pittsburgh, Pittsburgh, PA

Work History

2015-Present: Assistant Researcher, Department of Pharmaceutical Chemistry, University of California, San Francisco
2013-2015: Postdoctoral Employee, Department of Pharmaceutical Chemistry, University of California, San Francisco
2010-2012: Postdoctoral Fellow, Molecular Carcinogenesis, National Institute of Environmental Health Sciences (NIEHS), Durham, NC

Research Interests

I am interested in development and optimization of strategies for large scale isolation of posttranslational modified proteins, including phosphorylation, O-GlcNAcylation, and ubiquitinylation, from different cell and tissue types. While at Duke University, I was trained in cell and molecular biology while I studied the endoplasmic reticulum chaperone GRP94 and its role in Drosophila development and gut function.

Select Publications

Kim S, Maynard JC, Strickland A, Burlingame AL, Milbrandt J. Schwann cell O-GlcNAcylation promotes peripheral nerve remyelination via attenuation of the AP-1 transcription factor JUN. Proc Natl Acad Sci U S A. 2018 07 31; 115(31):8019-8024 PMID: 30012597. PMCID: PMC6077742 [Pubmed]

Kim S, Maynard JC, Sasaki Y, Strickland A, Sherman DL, Brophy PJ, Burlingame AL, Milbrandt J. Schwann Cell O-GlcNAc Glycosylation Is Required for Myelin Maintenance and Axon Integrity. J Neurosci. 2016 Sep 14; 36(37):9633-46. PMID: 27629714. PMCID: PMC5039245 [Pubmed]

Maynard JC, Burlingame AL, Medzihradszky KF. Cysteine S-linked N-acetylglucosamine (S-GlcNAcylation), A New Post-translational Modification in Mammals. Mol Cell Proteomics. 2016 Nov; 15(11):3405-3411. PMID: 27558639. PMCID: PMC5098038 [Pubmed]

Maynard JC, Rankin HB, Pham T, Zheng T, Newgard CB, Spana EP, Nicchitta CV. Gp93, the Drosophila GRP94 ortholog, is required for gut epithelial homeostasis and nutrient assimilation-coupled growth control. Dev Biol. 339(2) 295–306. (2010) [Pubmed]

Chu F, Maynard JC, Chiosis G, Nicchitta CV, Burlingame AL. Identification of novel quaternary domain interactions in the Hsp90 chaperone, GRP94. Protein Sci. 15(6)1260–9. [Pubmed]


National Institute of General Medical Sciences Adelson Medical Research Foundation