David Maltby
Position
Specialist, Facility Manager
Education
| M.Sc. | Biochemistry | 1978 | Michigan State University, East Lansing, MI |
| B.Sc. | Biochemistry | 1974 | Michigan State University, East Lansing, MI |
Work History
| 1994-Present: | Specialist, Mass Spectrometry Facility, UCSF, CA. |
| 1987-1993: | Associate Specialist, Mass Spectrometry Facility, UCSF, CA. |
| 1982-1987: | Laboratory Research Analyst, Department of Pediatrics, Duke University Medical Center, Durham, NC. |
| 1978-1982: | Laboritory Research Technician, Analytical Toxicology Lab and Animal Health and Diagnostics Lab, Michigan State University, East Lansing, MI. |
Research Interests
I am the manager of the mass spectrometry facility service laboratory. As such, I am responsible for instrument maintenance, instrument tuning and setup, training of new personnel and the analyses of that component of our samples that is considered of a service nature (as opposed to collaborative projects).
I received my undergraduate and graduate education at Michigan State University. I started in the field of Mass spectrometry in 1979 while working on a Finnigan quadruple GCMS instrument. I received advanced training in mass spectrometry from Dr. David Millington while working for him at the University of North Carolina and then Duke University. I joined the UCSF facility in 1987. In addition to the duties listed above I spend a large segment of my time on methods development (both MS and chromatography) and optimization of the facility's instrumentation including the many HPLC systems in the lab.
Select Publications
Keatinge-Clay, A.T., Maltby, D.A., Medzhiradszky, K.F., Khosla, C., and Stroud R.M., An antibiotic factory caught in action, Nat Struct Mol Biol, 11, 888-893 (2004). [Pubmed]
Huang, L., Baldwin, M.A., Maltby, D.A., Medzihradszky, K.F., Baker, P.R., Allen, N., Rexach, M., Edmondson, R.D., Campbell, J., Juhasz, P., Martin, S.A., Vestal, M.L., and Burlingame, A.L., The identification of protein-protein interactions of the nuclear pore complex of Saccharomyces cerevisiae using high throughput matrix-assisted laser desorption ionization time-of-flight tandem mass spectrometry, Mol Cell Proteomics, 1, 434-450 (2002). [Pubmed]
Wang, X., Medzihradszky, K.F., Maltby, D., and Correia, M.A., Phosphorylation of native and heme-modified CYP3A4 by protein kinase C: a mass spectrometric characterization of the phosphorylated peptides, Biochemistry, 40, 11318-11326 (2001). [Pubmed]
Moradian-Oldak, J., Jimenez, I., Maltby, D., and Fincham, A.G., Controlled proteolysis of amelogenins reveals exposure of both carboxy- and amino-terminal regions, Biopolymers, 58, 606-616 (2001). [Pubmed]
He, K., Bornheim, L.M., Falick, A.M., Maltby, D, Yin, H., and Correia, M.A., Identification of the heme-modified peptides from cumene hydroperoxide-inactivated cytochrome P450 3A4, Biochemistry, 37, 17448-17457 (1998). [Pubmed]