Alexandra Ioanoviciu
Position
Postdoctoral Fellow
Education
| Ph.D. | Medicinal Chemistry | 2005 | Purdue University, West Lafayette, IN |
| B.Sc. | Pharmacy | 2000 | Iuliu Hatieganu University, Romania |
Work History
| 2005-Present: | Postdoctoral Fellow, Department of Pharmaceutical Chemistry, University of California, San Francisco |
Research Interests
I am interested in the field of protein biochemistry and the detection of posttranslational modifications using mass spectrometric methods. The focus of my work is the study of O-GlcNAcylation and its interplay with phosphorylation in samples isolated from murine brains. This research is expected to provide insights into the role of posttranslational modifications in neuronal physiology and in the development of neurodegenerative conditions such as Alzheimer’s disease.
Select Publications
Ioanoviciu, A., Meharenna, Y.T., Poulos, T.L., Ortiz de Montellano, P.R., DevS Oxy Complex Stability Identifies this Heme Protein as a Gas Sensor in Mycobacterium tuberculosis Dormancy, Biochemistry 48, 5839-5848 (2009). [Pubmed]
Ioanoviciu, A., Yukl, E.T., Moënne-Loccoz, P., and Ortiz de Montellano, P.R., DevS, a Heme-Containing Two-Component Oxygen Sensor of Mycobacterium tuberculosis, Biochemistry 46, 4250-4260 (2007). [Pubmed]
Marchand, C., Antony, S., Kohn, K.W., Cushman, M., Ioanoviciu, A., Staker, B.L., Burgin, A.B., Stewart, L., Pommier, Y., A Novel Norindenoisoquinoline Structure Reveals a Common Interfacial Inhibitor Paradigm for Ternary Trapping of the Topoisomerase 1-DNA Covalent Complex, Mol. Cancer Ther. 5, 287-295 (2006). [Pubmed]
Ioanoviciu, A., Antony, S., Pommier, Y., Staker, B.L., Stewart, L., Cushman, M., Synthesis and Mechanism of Action Studies of a Series of Norindenoisoquinoline Topoisomerase I Poisons Reveal an Inhibitor with a Flipped Orientation in the Ternary DNA-Enzyme-Inhibitor Complex as Determined by X-ray Crystallographic Analysis, J. Med. Chem. 48, 4803-4814 (2005). [Pubmed]