Shannon Michelle Eliuk
Position
Postdoctoral Fellow
Education
| Ph.D. | Pharmacology and Toxicology | 2008 | University of Alabama at Birmingham, Birmingham, AL |
| B.Sc. | Biology | 2003 | University of Alberta, Edmonton, Alberta, Canada |
Work History
| 2008-Present: | Postdoctoral Fellow, Mass Spectrometry Facility, UCSF, San Francisco, CA |
Research Interests
My current research interests are in the area of protein biochemistry. In particular, I have a great interest in post-translational modifications that are associated with regulatory mechanisms and/or epigenetic processes. Advancements in the field of mass spectrometry, including the introduction of high resolution/high mass accuracy instruments such as the LTQ FT and the LTQ Orbitrap, are particularly useful in the site-specific localization of these post-translational modifications for the determination of their functional consequences at a cellular level.
Select Publications
Shonsey, E.M., Eliuk, S.M., Johnson, M.S., Barnes, S., Falany, C.N., Darley-Usmar, V.M., and Renfrow, M.B., Inactivation of human liver bile acid CoA:amino acid N-acyltransferase by the electrophilic lipid, 4-hydroxynonenal, J Lipid Res 49(2), 282-294 (2008). [Pubmed]
Kim, H., Eliuk, S., Deshane, J., Meleth, S., Sanderson, T., Pinner, A., Robinson, G., Wilson, L., Kirk, M., and Barnes, S. 2D gel proteomics: an approach to study age-related differences in protein abundance or isoform complexity in biological samples, Methods Mol Biol 371, 349-391 (2007). [Pubmed]
Eliuk, S.M., Renfrow, M.B., Shonsey, E.M., Barnes, S., and Kim, H., Active Site Modifications of the Brain Isoform of Creatine Kinase by 4-Hydroxy-2-nonenal Correlate with Reduced Enzyme Activity: Mapping of Modified Sites by Fourier Transform-Ion Cyclotron Resonance Mass Spectrometry, Chem Res Toxicol., 20(9), 1260-1268 (2007). [Pubmed]
Kim, H., Eliuk, S., Deshane, J., Barnes, S., Meleth, S., Nutriproteomics Approach to Understanding Dementia-Relevant Brain Protein Changes in Response to Grape Seed Extract, a Dietary Antioxidant in Oxidative Stress and Age-Related Neurodegeneration, (Yuan Luo, ed) Boca Raton, FL: CRC Press, 457-480 (2005).