Jordane Biarc
Position
Postdoctoral Fellow
Education
| Ph.D. | Molecular and Cellular Pharmacology | 2004 | University Louis Pasteur, Strasbourg, France |
| M.Sc. | Biology and Chemistry | 2000 | University Louis Pasteur, Strasbourg, France |
| B.Sc. | Biochemistry | 1998 | University Louis Pasteur, Strasbourg, France |
Work History
| 2007-Present: | Postdoctoral Fellow, Mass Spectrometry Facility, UCSF, San Francisco, CA. |
| 2005-2007: | Postdoctoral Fellow, CHUL, Université Laval, Québec City, Canada. |
Research Interests
Characterization of the tropomyosin-related receptor kinase A (TrkA) signaling pathway. The activation of the receptor tyrosine kinase, TrkA, by the NGF (Nerve Growth Factor) leads to the phosphorylation of several tyrosines in the intracellular part of the receptor. Two phosphotyrosines located at 490 and 785 create docking sites for adaptator or effector proteins which stimulate several signaling pathways. My research interest is focused in characterizing the signaling pathways specifically activated by these 2 phosphotyrosines by using chimeras receptors. I am also interested in characterizing the substrates of the tyrosine kinase domain of TrkA by using an engineered kinase in immortalized dorsal root ganglion cells. This project will further understanding of the function of the NGF receptor in neurons.
Select Publications
Leclerc, P., Biarc, J., St-Onge, M., Gilbert, C., Dussault, A.A., Laflamme, C., Pouliot, M., Nucleobindin co-localizes and associates with cyclooxygenase (COX)-2 in human neutrophils,PLoS ONE, 3(5), e2229 (2008). [Pubmed]
Biarc, J., Nguyen, I.S., Pini, A., Gossé, F., Richert, S., Thiersé, D., Van Dorsselaer, A., Leize-Wagner, E., Raul, F., Klein, J-P. and Schöller-Guinard, M., Carcinogenic properties of proteins with pro-inflammatory activity from Streptococcus infantarius (formerly S. bovis), Carcinogenesis 25, 1477-84 (2004). [Pubmed]
St-Onge, M., Flamand, N., Biarc, J., Picard, S., Bouchard, L., Dussault, A.A., Laflamme, C., James, M.J., Caughey, G.E., Cleland, L.G., Borgeat, P., Pouliot, M., Characterization of prostaglandin E2 generation through the cyclooxygenase (COX)-2 pathway in human neutrophils, Biochim Biophys Acta. 1771(9), 1235-45 (2007). [Pubmed]